Agenus (NASDAQ:AGEN) & CytRx (NASDAQ:CYTR) Financial Review

Agenus (NASDAQ:AGEN) and CytRx (NASDAQ:CYTR) are both small-cap medical companies, but which is the better stock? We will compare the two companies based on the strength of their valuation, earnings, analyst recommendations, institutional ownership, dividends, profitability and risk.


This table compares Agenus and CytRx’s net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Agenus N/A N/A -56.05%
CytRx N/A -34.37% -24.73%

Risk & Volatility

Agenus has a beta of 1.82, meaning that its share price is 82% more volatile than the S&P 500. Comparatively, CytRx has a beta of 2.16, meaning that its share price is 116% more volatile than the S&P 500.

Institutional and Insider Ownership

33.1% of Agenus shares are owned by institutional investors. Comparatively, 7.9% of CytRx shares are owned by institutional investors. 5.2% of Agenus shares are owned by company insiders. Comparatively, 6.6% of CytRx shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a company is poised for long-term growth.

Analyst Recommendations

This is a breakdown of current ratings and recommmendations for Agenus and CytRx, as provided by MarketBeat.

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Agenus 0 0 1 0 3.00
CytRx 0 0 1 0 3.00

Agenus currently has a consensus target price of $5.00, indicating a potential upside of 66.11%. CytRx has a consensus target price of $5.00, indicating a potential upside of 1,415.15%. Given CytRx’s higher possible upside, analysts plainly believe CytRx is more favorable than Agenus.

Earnings and Valuation

This table compares Agenus and CytRx’s gross revenue, earnings per share and valuation.

Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio
Agenus $36.78 million 10.99 -$159.69 million ($1.44) -2.09
CytRx $250,000.00 44.40 -$12.71 million ($0.29) -1.14

CytRx has lower revenue, but higher earnings than Agenus. Agenus is trading at a lower price-to-earnings ratio than CytRx, indicating that it is currently the more affordable of the two stocks.


CytRx beats Agenus on 8 of the 11 factors compared between the two stocks.

About Agenus

Agenus Inc., a clinical-stage immuno-oncology company, focuses on the discovery and development of therapies that engage the body's immune system to fight cancer. The company offers Retrocyte Display, an antibody discovery platform for the identification of fully-human and humanized monoclonal antibodies; SECANT yeast display, an antibody discovery platform used for the generation of novel monoclonal antibodies; and phage display technologies. It is also developing checkpoint modulating antibody candidates targeting GITR, OX40, TIM-3, LAG-3, and others. In addition, the company develops vaccine programs, including Prophage vaccine candidate; AutoSynVax, a synthetic neoantigen; and PhosPhoSynVax, a vaccine candidate designed to induce immunity against a class of tumor specific neoepitopes. Further, it develops QS-21 Stimulon adjuvant, a saponin-based vaccine adjuvant. Additionally, the company engages in the development of CTLA-4 and PD-1 antagonists; and anti-CTLA-4, CD137, and TIGIT antibodies, as well as various multi-specific antibodies that are under various stages of development. Agenus Inc. has collaboration agreements with Incyte Corporation, Merck Sharpe & Dohme, and Recepta Biopharma SA.; and collaboration with Gilead Sciences, Inc. to develop immuno-oncology therapies. The company was formerly known as Antigenics Inc. and changed its name to Agenus Inc. in January 2011. Agenus Inc. was founded in 1994 and is headquartered in Lexington, Massachusetts.

About CytRx

CytRx Corporation, a biopharmaceutical company, engages in the research and clinical development of novel anti-cancer drug candidates that employ linker technologies to enhance the accumulation and release of drug at the tumor. The company is developing its pipeline of oncology candidates at its laboratory facilities in Freiburg, Germany, through its LADR (linker activated drug release) technology platform, a discovery engine designed to leverage its expertise in albumin biology and linker technology for the development of anti-cancer therapies. Its lead drug candidate is Aldoxorubicin, an improved version of anti-cancer drug doxorubicin out-licensed to NantCell, Inc. Aldoxorubicin is in late-stage clinical development for the treatment of relapsed soft tissue sarcoma, as well as evaluating in various other cancer indications with unmet clinical need, including small-cell lung cancer. CytRx Corporation was founded in 1985 and is headquartered in Los Angeles, California.

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